09.30 – 12.30

PRECONGRESS WORKSHOP 1: Fetal growth in twin pregnancy

Course Coordinators: Kurt Hecher (Germany); Asma Khalil (United Kingdom)

Discussants: Kurt Hecher (Germany); Asma Khalil (United Kingdom); Isaac Blickstein (Israel); Liesbeth Lewi (Belgium); Gerard H.A. Visser (The Netherlands)

How to monitor intrapartum?
Diogo Ayres De Campos (Portugal)

How to assess fetal growth in multiple pregnancy?
Isaac Blickstein (Israel)

Discordance in twins: is it ominous sign?
Asma Khalil (United Kingdom)

Selective fetal growth restriction: definition and outcome
Kurt Hecher (Germany)

Selective fetal growth restriction: management options
Mar Bennasar (Spain)

Selective fetal growth restriction: when and how to deliver
Liesbeth Lewi (Belgium)

09.00 – 12.30

PRECONGRESS WORKSHOP 2: Twins and Epigenetics

Course Coordinator: Jordana Bell (United Kingdom); Miina Ollikainen (Finland)

The heritability of DNA methylation and links to human traits: insights from twin studies
Jenny van Dongen (The Netherlands)

Leisure-time physical activity shows no effect on DNA methylation age in discordant twin study

Elina Sillanpää (Finland)

Epigenetic studies of twins: insights into nonshared environment
Jeff Craig (Australia)

Epigenome-wide analysis of DNA methylation using monozygotic twins discordant for epilepsy
Namitha Mohandas (Australia)

10.00 – 16.00

PRECONGRESS WORKSHOP 3: Managing a national multiple birth organisation (for ICOMBO members)

Course Coordinator: Monica Rankin (Australia)

Opening and welcome
Monica Rankin (ICOMBO, Australia)

An introduction to the Elizabeth Bryan Multiple Births Centre, formerly the Multiple Births Foundation
Jane Denton (Elizabeth Bryan Multiple Births Centre, United Kingdom) 

Introduction to ICOMBO members
Monica Rankin (ICOMBO, Australia)

Purple Butterfly Initiative
Ashlee Tenberge (Australian Multiple Birth Association, Australia)

Update on Tamba activities – Foetal growth charts; latest findings from a report on stillbirth, neonatal death, neonatal admissions and patient safety incidents; Tamba Maternity engagement program.
Keith Reed, Amy McCarthy (United Kingdom)

The Diverse Families network and their project – Finland for all Families
Ulla Kumpula (Finnish Multiple Birth Association, Finland)

Open forum on the following topics:

– Has anyone created a database of twins for different purposes (for advertising, films, research, etc). Is it successful? Any pitfalls?

– How to obtain new/younger members and then retain them

– How to encourage volunteers, not only at the local club level, but at the national level

– How to find quality speakers at a reasonable price, or people who would be willing to donate their services to a non-profit organization

– The structural challenges of building a strong and aligned organisation

– What is your not-for-profit status and how do you access funding?

– Any other topics for discussion? Bring your ideas and suggestions

Closing remarks

13.30 – 17.00

PRECONGRESS WORKSHOP 4: Fetal therapy in multiple pregnancy

Course Coordinator: Ruben Quintero (USA); Eugenia Antolin (Spain)

Discussants: Eugenia Antolin (Spain); Josè Louis Bartha Rasero (Spain); Ramen Chmait (USA); Eftichia Kontopoulos (USA); Ruben Quintero (USA)

The Great Monochorionic Syndromes: indications and techniques
Ruben Quintero (United States)

Selective fetal reduction in monochorionic twins: indications and tecniques
Eugenia Antolin (Spain)

Umbilical cord occlusion in monochorionic twins: technical considerations
Ramen Chmait (United States)

Expectant management vs. laser therapy in selective intrauterine growth restriction
Eftichia Kontopoulos (United States)

The placentation in twins and its challenges
Jose Louis Bartha Rasero (Spain)

Rethinking TAPS
Ruben Quintero (United States)

13.30 – 16.00

PRECONGRESS WORKSHOP 5: Establishing a twin register: wonderful resources for phenotyping and biobanking

Course Coordinator: Dorret Boomsma (The Netherlands)

To represent a well-established twin register
Nick Martin (Australia)

The relatively recent southern EU experience
Juan Ramon Ordonana (Spain)

The new Moscow newborn twin study experience
Veronika Odintsova (Russia)

Zygosity assessment from immediate GSA genotyping
Jouke Jan Hottenga (The Netherlands)

Possibilities for biobanking in twin registers
Eline Slagboom (The Netherlands)

Providing feedback via a participant portal: Experiences from the Netherlands Twin Register
Gonneke Willemsen (The Netherlands)

16.15 – 17.45

ISTS BOARD MEETING

Coordinators: Gonneke Willemsen (Netherlands); Jennifer Harris (Norway)

16.15 – 17.45

EARLY CARREER RESEARCHER MEETING

Coordinators: Jaakko Kaprio (Finland); Lucas Calais Ferreira (Australia)

18.00 – 21.00

OPENING CEREMONY & WELCOME RECEPTION

Chairpersons: Gian Carlo Di Renzo (Italy); Ruben Quintero (United States); Jennifer Harris (Norway); Josè Louis Bartha Rasero (Spain)

OPENING LECTURE:

Assessing Telomere Length and Telomerase Activity in Twin Astronauts
Susan Bailey (USA)

 

“TWIN” welcome reception

08.30 – 09.30

PARALLEL SESSION 1A:  Well-being

Coordinator: Meike Bartels (The Netherlands)

Findings from Norwegian twin studies on wellbeing
Ragnhild Bang Nes (Norway)

Genome and Epigenome findings for wellbeing
Bart Baselmans (The Netherlands)

Wellbeing and the brain
Meike Bartels (The Netherlands)

Sleep and well-being: quality and duration of sleep relate differently with health-related quality of life
Juan J. Madrid-Valero (Spain)

08.30 – 09.30

PARALLEL SESSION 1B: Perinatal mortality and morbidity in multiple pregnancy

Coordinator: Gerard H.A. Visser (The Netherlands)

Perinatal mortality in twins – Gerard H.A. Visser (The Netherlands)

How to avoid stillbirth in twins? – Asma Khalil (United Kingdom)

Single twin demise – Mark Kilby (United Kingdom)

09.30 – 10.00

KEYNOTE LECTURE

Introduced by: Gian Carlo Di Renzo (Italy)

  • Progesterone for the prevention of preterm birth in twin gestations: two parallel stories
    Roberto Romero (United States)

10.00 – 10.30

COFFEE BREAK & POSTER VIEW WITH FOCUS ON:

– BIOLOGY OF TWINNING

– INFECTIONS AND MATERNAL DISEASES

– MONITORING IN PREGNANCY

10.30 – 12.30

PARALLEL SESSION 2A: Bulmer session on new developments with the biology of twinning  

Coordinators: Catherine Derom (Belgium); Nils Lambalk (The Netherlands)

This symposium deals with the biology and genetics of the twinning phenomenon. Name of this symposium: book by Michael Bulmer:  “The Biology of Twinning in Man”

The genetics of dizygotic twinning: the Twinning Genetics Consortium
Hamdi Mbarek (The Netherlands)

Biology of monozygotic twinning
Claudio Stern (United Kingdom)

The biology of double implantation of embryos
Robbert Berkhout (The Netherlands)

Chimerism in DZ twins: an overview and clinical relevance
Henrike Peters (The Netherlands)

Are monochorionic twins monozygotic?
Catherine Derom (Belgium)

Monochorionic dizygotic twins are not rare: evidence from a twin birth cohort
Jeff Craig (Australia)

GWAS for DZ twinning in a new sample of Australian families
Nick Martin (Australia)

10.30 – 12.30

PARALLEL SESSION 2B: Preconceptional aspects of multiple pregnancy

Course Coordinator: Lali Sichinava (Russia); Isaac Blickstein (Israel)

Twins and socioeconomic factors
Ariadne Malamitsi-Puchner (Greece)

Mono- or bi-chorionicity: which does really matter?
Isaac Blickstein (Israel)

Placental development and complications in twin pregnancy
Josè Louis Bartha Rasero (Spain)

Customised growth chart in twins
Giuseppe Rizzo, Manuela Veglia (Italy)

Counselling and techniques for multiple pregnancy reduction
Aris Antsaklis (Greece)

10.30 – 12.30

PARALLEL SESSION 2C:  Twin-related complication

Coordinator: Kurth Hecher (Germany); Gian Carlo Di Renzo (Italy)

Outcome of complicated twin pregnancy: how to counsel the parents?
Enrico Lopriore (The Netherlands)

Neurodevelopmental morbidity in monochorionic twins
Kurt Hecher (Germany)

The placenta in complicated twin pregnancy
Liesbeth Lewi (Belgium)

Timing of cord clamping
Lianne Verbeek (The Netherlands)

Twins and neurodevelopmental outcomes: the effect of IVF, fetal growth restriction and preterm birth
Despina Briana (Greece)

Birth Weight Discordance And Adverse Perinatal Outcomes
Shayesteh Jahandar (United States)

Vanished twin: obstetric and perinatal outcomes and association with methylenetetrahydrofolate reductase (MTHFR) polymorphisms(s)
Murat Ayut Ozek (Turkey)

12.30 – 13.30

LUNCH BREAK & POSTER VIEW WITH FOCUS ON:

– DELIVERY OF TWINS

– EPIGENOMICS

– PRECONCEPTIONAL ASPECTS OF MULTIPLE PREGNANCY

– WELL BEING

– POLYGENIC RISK SCORES

13.30 – 15.30

PARALLEL SESSION 3A:  Obstetrical issues in twin pregnancy: prenatal screening and diagnosis

Coordinator: Katia Bilardo (The Netherlands); Liona Poon (Hong Kong)

NIPT in twin pregnancy
Maria Del Mar Gil Mira (Spain)

Management of discordant anomaly in twin pregnancy
Mark Kilby (United Kingdom)

First trimester prediction in twin pregnancy
Giuseppe Rizzo, Manuela Veglia (Italy)

Functional and acquired cardiovascular anomalies in monochorionic twins
Nicky Manning (United Kingdom)

Prediction of major obstetrical syndromes in twin pregnancy in first trimester
Liona Poon (Hong Kong)

13.30 – 15.30

PARALLEL SESSION 3B: Early Career Researchers: Network, Collaboration and Science

Coordinators: Jaakko Kaprio (Finland); Lucas Calais Ferreira (Australia)

Building networks, capacity and the new workforce in global twin research
Lucas Calais Ferreira (Australia)

The CODATwins project: An example of international collaboration in twin research
Aline Jelenkovic (Finland)

The career of a staff scientist – combining a scientific background with administrative tasks in a research environment
Inge Petersen (Denmark)

Variant anatomy of the circle of Willis: an MRI twin study
Bianka Forgo (Hungary)

Is the association between obesity and hip osteoarthritis explained by familial confounding? Results from the Nor-Twin OA study
Karin Magnusson (Norway)

The Twins Research Australia Health and Lifestyle questionnaire
Tessa Cutler (Australia)

Discussion panel

PARALLEL SESSION 3C: HEALTH and WELL-BEING for the MULTIPLE BIRTH FAMILY

Coordinator: Monica Rankin (Australia)

Mental Health and the Multiple Birth Family: Antenatal and Postnatal Groups
Gretta Little (Australia)

Single Parenting of Multiple Birth Children
Susan Griffith (United States)

The Multiple Birth Single Parents Experiences of their Daily Lives
Kristiina Heinonen (Finland)

The Challenges faced by Twins, Multiples and their Families: Experiences in the UK and Australia
Keith Reed (United Kingdom)

“What About us?” Negotiating the Realities of Parenting Multiples during the First Five Years
Laura Maguire (United Kingdom)

The Twins in Pedagogical Practice
Klara Vitkova Rulikova (Czech Republic)

Some Aspects of Parental Support for Twins’ Education
Kristiina Heinonen (Finland)

15.30 – 16.30

COFFEE BREAK

– OTHERS

16.30 – 18.30

PARALLEL SESSION 4A:  Preterm birth and prematurity (a PREIS School Academy session)

Coordinators: Roberto Romero (USA); Luis Cabero Roura (Spain)

Preterm birth syndrome and its implications for twins
Roberto Romero (USA)

Preterm birth in twins: where are we now?
Jon Barrett (Canada)

Screening for preterm birth in twin pregnancy
Julien Stirnemann, Yves Ville (France)

Pessary in twin pregnancy
Birgit Arabin (Germany)

New tools for preventing preterm birth
Fabio Facchinetti (Italy)

SHORT COMMUNICATION: Trans abdominal cerclage in twins: series of 7 cases
Frederic Debieve (Belgium)

16.30 – 18.30

PARALLEL SESSION 4B: Epigenomics and twin studies

Coordinators: Jeffrey Craig (Australia); Robert Lyle (Norway)

Methylome-wide association study of aggressive behavior in monozygotic twins
Jenny Van Dongen (Netherlands)

Hormone replacement therapy -related DNA methylation, gene expression and mir profiles associate with within-pair differences in clinical measures
Miina Ollikainen (Finland)

A genome-wide profiling of epigenetic fingerprint in adult twins of preterm birth.
Qihua Tan (Denmark)

The relevance of peripheral DNA methylation for human brain development and emotional functioning: studies in monozygotic twins
Linda Booij (Canada)

Circulating microRNA biomarkers and cognitive function in elderly Danish twins
Jonas Mengel-From (Denmark)

A twin model for making causal inference: applications to observational epigenetic associations
Shuai Li (Australia)

Cigarette smoking, circulating levels of immune and inflammatory markers and epigentics in monozygotic twins
Wendy Cozen (Unites States)

Epigenetic signatures of prenatal growth control
Marij Gielen (The Netherlands)

18.30 – 19.30

ISTS GENERAL MEETING

08.30 – 09.30

PARALLEL SESSION 5A: Care in pregnancy and labour

Course Coordinator: Eftichia Kontopoulos (USA); Gerard Visser (The Netherlands)

Fetal growth restriction in twin pregnancy
Mar Bennasar (Spain)

Intrapartum care in twins pregnancy
Efticha Kontopoulos (United States)

Can 3D printing help for the monitoring of twin pregnancy?
Irene Giardina (Italy); Graziano Clerici (Italy); Gian Carlo Di Renzo (Italy)

08.30 – 09.30

PARALLEL SESSION 5B: Polygenic Risk Scores and twin studies

Coordinator: Sarah Medland (Australia)

Construction and use of PRS
Sarah Medland (Australia)

PRS and the study of GxE interactions
Lucia Colodro Conde (Australia)

PRS in Mendelian Randomization
Baptiste Couvy-Duchesne (Australia)

09.30 – 10.00

KEYNOTE LECTURE 

Introduced by: Jennifer Harris (Norway)

Twin studies of obesity: an epigenetic and microbiome perspective
Jordanna Bell (United Kingdom)

10.00 – 10.30

COFFEE BREAK & POSTER WALK WITH FOCUS ON

– SPECIAL ISSUES: TTTS, TAPS, MCMA

10.30 – 12.30

PARALLEL SESSION 6A:  Special issues: TTTS, TAPS, MCMA

Coordinators: Ruben Quintero (USA); Mark Kilby (United Kingdom)

Management of MCMA twins
Kurt Hecher (Germany)

TTTS in triplets
Asma Khalil (United Kingdom)

Debate: traditional selective laser photocoagulation of communicating vessels (SLPCV) approach for managing TTTS
Ruben Quintero (USA) 

Brain abnormalities
Julien Stirnemann (France)

Long term neurodevelopmental outcome of MC twins
Jeanine van Klink (The Netherlands)

Fetoscopic laser photocoagulation in twin-to-twin transfusion syndrome
Kristina Gladkova (Russia)

10.30 – 12.30

PARALLEL SESSION 6B: Symposium in honor of Irv Gottesman 

Organizer: Nancy Segal (United States)
Discussant: Kaare Christensen (Denmark)

Dr. Irving I. Gottesman was a pioneer in the field of twin research, as well as a wonderful colleague, mentor and friend to the scores of individuals with whom he worked. This symposium honors his legacy and in doing so keeps it alive as an inspiration for future investigators. An overview of his professional contributions and papers from his former students and colleagues will be presented, followed by comments from the audience.

Introductory Remarks
Nancy Segal (United States)

Gene-Environment Correlations Affecting Children’s Early Delinquency and Aggressive Play Behaviors
Lisabeth Di Lalla and David Dilalla (United States)

From Genes to Behavior Through Sex Hormones and Socialization: The Example of Gender Development
Sheri Berenbaum, Adriene M. Beltz (United States)

Twins Reared Apart: The Findings Behind the Fascination
Nancy Segal (United States)

Irv Gottesman and the Possibilities for Theoretical Behavioral Genetics
Eric Turkheimer (United States)

Mapping Risk from Genes to Behavior
Danielle Dick (United States)

Comments and recollections from the audience

Closing Comments

12.30 – 13.30

LUNCH BREAK & POSTER WALK WITH FOCUS ON

– PERINATAL MORTALITY AND MORBIDITY IN MULTIPLE PREGNANCY

– PRENATAL SCREENING AND DIAGNOSIS IN TWINS PREGNANCY

13.30 – 15.30

PARALLEL SESSION 7A:  Delivery of twins: Cesarean delivery, PPH

Coordinators: Gerard H.A. Visser (The Netherlands); Jon F. Barrett (Canada)

When is the optimal timing to deliver uncomplicated twins?
Jon F. Barrett (Canada)

Mode of Delivery
Amala Nazareth (EAU)

Induction of labour in Twins
Maria De La Calle (Spain)

Prevention and management of PPH in multiple pregnancy
Anton Mikhailov (Russia)

Debate: all monochorionic twins should be delivered by CS
YES: Corinne Hubinont (Belgium)
NO: Jan G. Nijhuis (The Netherlands)

13.30 – 15.30

PARALLEL SESSION 7B: participant engagementand user involvement in twin research: let’s talk about lessons learned and ideas going forward

Coordinators: Jennifer Harris (Norway), Monica Rankin (Australia), Jeffrey Craig (Australia) 

Research funding agencies are increasingly focused on participant engagement and user involvement in the research process to help improve the quality and usefulness of the research.

What are the types of participant engagement and/or user involvement that twin studies have used and how have these helped in the research process? This session will include several short talks describing experiences and approaches with user involvement and engagement in twin studies. It is designed as an interactive session that will include a panel discussion.

User involvement and participant engagement
Jennifer Harris, Isabelle Budin-Ljøsne (Norway)

Strategies for participant engagement and lessons learned from ICOMBO
Monica Rankin (Australia)

Vietnam Era Registries: Engagement through focus groups
Nicolas Smith (USA)

Engaging with twins and their families – an Australian perspective
Jeff Craig (Australia)

Consent and feedback: Issues and Solutions
Gonneke Willemsen (The Netherlands)

 

 

Discussion Panel

Isabelle Budin-Ljøsne (Norway)

Thalia Eley (United Kingdom)

Jeff Craig (Australia)

Jack Goldberg (United States)

Monica Rankin (Australia)

Nancy Segal (United States)

Nicolas Smith (United States)

Gonneke Willemsen (The Netherlands)

15.30 – 16.30

COFFEE BREAK & POSTER WALK WITH FOCUS ON

– PRETERM BIRTH AND PREMATURITY

– TWIN-RELATED COMPLICATIONS

16.30 – 18.30

PARALLEL SESSION 8A:  Special issues: Infections, Maternal diseases

Coordinators: Liesbeth Lewi (Belgium); Jan G. Nijhuis (The Netherlands)

Insulin resistance and metabolic abnormalities in birthweight discordant twins

Iwona Szymusik, Miroslaw Wielgos (Poland)

Gestational diabetes and multiple pregnancy – A 10 year retrospective of obstetric complications and neonatal outcomes
Filipa Mendes Coutinho (Portugal)

Maternal morbidity according to chorionicity
Mark Kilby (United Kingdom)

The ELABELA-nergic Pathway as a Therapeutic Window for Pre-Eclampsia
Bruno Reversade (Singapore)

Thrombophilia and twin pregnancy
Liliana Voto (Argentina)

16.30 – 18.30

PARALLEL SESSION 8B: The use of twins in unravelling the Microbiome

Coordinators: Tim Spector (United Kingdom)

“Irritable Bowel Syndrome, Anxiety and Gut Microbiome – the Korean Healthy Twin Study”
Joohon Sung (South Korea)

Novel Twin Microbiome studies in Twins UK
Claire Steves (United Kingdom)

Differences in fecal microbiota in long-term hodgkin lymphoma survivors and their unaffected twins
Wendy Cozen (United States)

Cognitive performance is associated with the gut microbiota of community dwelling ageing adults
Serena Verdi (United Kingdom)

16.30 – 18.30

ICOMBO Business Meeting

18.30

CLOSING REMARKS

+ Thu 16th Nov

09.30 – 12.30

PRECONGRESS WORKSHOP 1: Fetal growth in twin pregnancy

Course Coordinators: Kurt Hecher (Germany); Asma Khalil (United Kingdom)

Discussants: Kurt Hecher (Germany); Asma Khalil (United Kingdom); Isaac Blickstein (Israel); Liesbeth Lewi (Belgium); Gerard H.A. Visser (The Netherlands)

How to monitor intrapartum?
Diogo Ayres De Campos (Portugal)

How to assess fetal growth in multiple pregnancy?
Isaac Blickstein (Israel)

Discordance in twins: is it ominous sign?
Asma Khalil (United Kingdom)

Selective fetal growth restriction: definition and outcome
Kurt Hecher (Germany)

Selective fetal growth restriction: management options
Mar Bennasar (Spain)

Selective fetal growth restriction: when and how to deliver
Liesbeth Lewi (Belgium)

09.00 – 12.30

PRECONGRESS WORKSHOP 2: Twins and Epigenetics

Course Coordinator: Jordana Bell (United Kingdom); Miina Ollikainen (Finland)

The heritability of DNA methylation and links to human traits: insights from twin studies
Jenny van Dongen (The Netherlands)

Leisure-time physical activity shows no effect on DNA methylation age in discordant twin study

Elina Sillanpää (Finland)

Epigenetic studies of twins: insights into nonshared environment
Jeff Craig (Australia)

Epigenome-wide analysis of DNA methylation using monozygotic twins discordant for epilepsy
Namitha Mohandas (Australia)

10.00 – 16.00

PRECONGRESS WORKSHOP 3: Managing a national multiple birth organisation (for ICOMBO members)

Course Coordinator: Monica Rankin (Australia)

Opening and welcome
Monica Rankin (ICOMBO, Australia)

An introduction to the Elizabeth Bryan Multiple Births Centre, formerly the Multiple Births Foundation
Jane Denton (Elizabeth Bryan Multiple Births Centre, United Kingdom) 

Introduction to ICOMBO members
Monica Rankin (ICOMBO, Australia)

Purple Butterfly Initiative
Ashlee Tenberge (Australian Multiple Birth Association, Australia)

Update on Tamba activities – Foetal growth charts; latest findings from a report on stillbirth, neonatal death, neonatal admissions and patient safety incidents; Tamba Maternity engagement program.
Keith Reed, Amy McCarthy (United Kingdom)

The Diverse Families network and their project – Finland for all Families
Ulla Kumpula (Finnish Multiple Birth Association, Finland)

Open forum on the following topics:

– Has anyone created a database of twins for different purposes (for advertising, films, research, etc). Is it successful? Any pitfalls?

– How to obtain new/younger members and then retain them

– How to encourage volunteers, not only at the local club level, but at the national level

– How to find quality speakers at a reasonable price, or people who would be willing to donate their services to a non-profit organization

– The structural challenges of building a strong and aligned organisation

– What is your not-for-profit status and how do you access funding?

– Any other topics for discussion? Bring your ideas and suggestions

Closing remarks

13.30 – 17.00

PRECONGRESS WORKSHOP 4: Fetal therapy in multiple pregnancy

Course Coordinator: Ruben Quintero (USA); Eugenia Antolin (Spain)

Discussants: Eugenia Antolin (Spain); Josè Louis Bartha Rasero (Spain); Ramen Chmait (USA); Eftichia Kontopoulos (USA); Ruben Quintero (USA)

The Great Monochorionic Syndromes: indications and techniques
Ruben Quintero (United States)

Selective fetal reduction in monochorionic twins: indications and tecniques
Eugenia Antolin (Spain)

Umbilical cord occlusion in monochorionic twins: technical considerations
Ramen Chmait (United States)

Expectant management vs. laser therapy in selective intrauterine growth restriction
Eftichia Kontopoulos (United States)

The placentation in twins and its challenges
Jose Louis Bartha Rasero (Spain)

Rethinking TAPS
Ruben Quintero (United States)

13.30 – 16.00

PRECONGRESS WORKSHOP 5: Establishing a twin register: wonderful resources for phenotyping and biobanking

Course Coordinator: Dorret Boomsma (The Netherlands)

To represent a well-established twin register
Nick Martin (Australia)

The relatively recent southern EU experience
Juan Ramon Ordonana (Spain)

The new Moscow newborn twin study experience
Veronika Odintsova (Russia)

Zygosity assessment from immediate GSA genotyping
Jouke Jan Hottenga (The Netherlands)

Possibilities for biobanking in twin registers
Eline Slagboom (The Netherlands)

Providing feedback via a participant portal: Experiences from the Netherlands Twin Register
Gonneke Willemsen (The Netherlands)

16.15 – 17.45

ISTS BOARD MEETING

Coordinators: Gonneke Willemsen (Netherlands); Jennifer Harris (Norway)

16.15 – 17.45

EARLY CARREER RESEARCHER MEETING

Coordinators: Jaakko Kaprio (Finland); Lucas Calais Ferreira (Australia)

18.00 – 21.00

OPENING CEREMONY & WELCOME RECEPTION

Chairpersons: Gian Carlo Di Renzo (Italy); Ruben Quintero (United States); Jennifer Harris (Norway); Josè Louis Bartha Rasero (Spain)

OPENING LECTURE:

Assessing Telomere Length and Telomerase Activity in Twin Astronauts
Susan Bailey (USA)

 

“TWIN” welcome reception

+ Fri 17th Nov

08.30 – 09.30

PARALLEL SESSION 1A:  Well-being

Coordinator: Meike Bartels (The Netherlands)

Findings from Norwegian twin studies on wellbeing
Ragnhild Bang Nes (Norway)

Genome and Epigenome findings for wellbeing
Bart Baselmans (The Netherlands)

Wellbeing and the brain
Meike Bartels (The Netherlands)

Sleep and well-being: quality and duration of sleep relate differently with health-related quality of life
Juan J. Madrid-Valero (Spain)

08.30 – 09.30

PARALLEL SESSION 1B: Perinatal mortality and morbidity in multiple pregnancy

Coordinator: Gerard H.A. Visser (The Netherlands)

Perinatal mortality in twins – Gerard H.A. Visser (The Netherlands)

How to avoid stillbirth in twins? – Asma Khalil (United Kingdom)

Single twin demise – Mark Kilby (United Kingdom)

09.30 – 10.00

KEYNOTE LECTURE

Introduced by: Gian Carlo Di Renzo (Italy)

  • Progesterone for the prevention of preterm birth in twin gestations: two parallel stories
    Roberto Romero (United States)

10.00 – 10.30

COFFEE BREAK & POSTER VIEW WITH FOCUS ON:

– BIOLOGY OF TWINNING

– INFECTIONS AND MATERNAL DISEASES

– MONITORING IN PREGNANCY

10.30 – 12.30

PARALLEL SESSION 2A: Bulmer session on new developments with the biology of twinning  

Coordinators: Catherine Derom (Belgium); Nils Lambalk (The Netherlands)

This symposium deals with the biology and genetics of the twinning phenomenon. Name of this symposium: book by Michael Bulmer:  “The Biology of Twinning in Man”

The genetics of dizygotic twinning: the Twinning Genetics Consortium
Hamdi Mbarek (The Netherlands)

Biology of monozygotic twinning
Claudio Stern (United Kingdom)

The biology of double implantation of embryos
Robbert Berkhout (The Netherlands)

Chimerism in DZ twins: an overview and clinical relevance
Henrike Peters (The Netherlands)

Are monochorionic twins monozygotic?
Catherine Derom (Belgium)

Monochorionic dizygotic twins are not rare: evidence from a twin birth cohort
Jeff Craig (Australia)

GWAS for DZ twinning in a new sample of Australian families
Nick Martin (Australia)

10.30 – 12.30

PARALLEL SESSION 2B: Preconceptional aspects of multiple pregnancy

Course Coordinator: Lali Sichinava (Russia); Isaac Blickstein (Israel)

Twins and socioeconomic factors
Ariadne Malamitsi-Puchner (Greece)

Mono- or bi-chorionicity: which does really matter?
Isaac Blickstein (Israel)

Placental development and complications in twin pregnancy
Josè Louis Bartha Rasero (Spain)

Customised growth chart in twins
Giuseppe Rizzo, Manuela Veglia (Italy)

Counselling and techniques for multiple pregnancy reduction
Aris Antsaklis (Greece)

10.30 – 12.30

PARALLEL SESSION 2C:  Twin-related complication

Coordinator: Kurth Hecher (Germany); Gian Carlo Di Renzo (Italy)

Outcome of complicated twin pregnancy: how to counsel the parents?
Enrico Lopriore (The Netherlands)

Neurodevelopmental morbidity in monochorionic twins
Kurt Hecher (Germany)

The placenta in complicated twin pregnancy
Liesbeth Lewi (Belgium)

Timing of cord clamping
Lianne Verbeek (The Netherlands)

Twins and neurodevelopmental outcomes: the effect of IVF, fetal growth restriction and preterm birth
Despina Briana (Greece)

Birth Weight Discordance And Adverse Perinatal Outcomes
Shayesteh Jahandar (United States)

Vanished twin: obstetric and perinatal outcomes and association with methylenetetrahydrofolate reductase (MTHFR) polymorphisms(s)
Murat Ayut Ozek (Turkey)

12.30 – 13.30

LUNCH BREAK & POSTER VIEW WITH FOCUS ON:

– DELIVERY OF TWINS

– EPIGENOMICS

– PRECONCEPTIONAL ASPECTS OF MULTIPLE PREGNANCY

– WELL BEING

– POLYGENIC RISK SCORES

13.30 – 15.30

PARALLEL SESSION 3A:  Obstetrical issues in twin pregnancy: prenatal screening and diagnosis

Coordinator: Katia Bilardo (The Netherlands); Liona Poon (Hong Kong)

NIPT in twin pregnancy
Maria Del Mar Gil Mira (Spain)

Management of discordant anomaly in twin pregnancy
Mark Kilby (United Kingdom)

First trimester prediction in twin pregnancy
Giuseppe Rizzo, Manuela Veglia (Italy)

Functional and acquired cardiovascular anomalies in monochorionic twins
Nicky Manning (United Kingdom)

Prediction of major obstetrical syndromes in twin pregnancy in first trimester
Liona Poon (Hong Kong)

13.30 – 15.30

PARALLEL SESSION 3B: Early Career Researchers: Network, Collaboration and Science

Coordinators: Jaakko Kaprio (Finland); Lucas Calais Ferreira (Australia)

Building networks, capacity and the new workforce in global twin research
Lucas Calais Ferreira (Australia)

The CODATwins project: An example of international collaboration in twin research
Aline Jelenkovic (Finland)

The career of a staff scientist – combining a scientific background with administrative tasks in a research environment
Inge Petersen (Denmark)

Variant anatomy of the circle of Willis: an MRI twin study
Bianka Forgo (Hungary)

Is the association between obesity and hip osteoarthritis explained by familial confounding? Results from the Nor-Twin OA study
Karin Magnusson (Norway)

The Twins Research Australia Health and Lifestyle questionnaire
Tessa Cutler (Australia)

Discussion panel

PARALLEL SESSION 3C: HEALTH and WELL-BEING for the MULTIPLE BIRTH FAMILY

Coordinator: Monica Rankin (Australia)

Mental Health and the Multiple Birth Family: Antenatal and Postnatal Groups
Gretta Little (Australia)

Single Parenting of Multiple Birth Children
Susan Griffith (United States)

The Multiple Birth Single Parents Experiences of their Daily Lives
Kristiina Heinonen (Finland)

The Challenges faced by Twins, Multiples and their Families: Experiences in the UK and Australia
Keith Reed (United Kingdom)

“What About us?” Negotiating the Realities of Parenting Multiples during the First Five Years
Laura Maguire (United Kingdom)

The Twins in Pedagogical Practice
Klara Vitkova Rulikova (Czech Republic)

Some Aspects of Parental Support for Twins’ Education
Kristiina Heinonen (Finland)

15.30 – 16.30

COFFEE BREAK

– OTHERS

16.30 – 18.30

PARALLEL SESSION 4A:  Preterm birth and prematurity (a PREIS School Academy session)

Coordinators: Roberto Romero (USA); Luis Cabero Roura (Spain)

Preterm birth syndrome and its implications for twins
Roberto Romero (USA)

Preterm birth in twins: where are we now?
Jon Barrett (Canada)

Screening for preterm birth in twin pregnancy
Julien Stirnemann, Yves Ville (France)

Pessary in twin pregnancy
Birgit Arabin (Germany)

New tools for preventing preterm birth
Fabio Facchinetti (Italy)

SHORT COMMUNICATION: Trans abdominal cerclage in twins: series of 7 cases
Frederic Debieve (Belgium)

16.30 – 18.30

PARALLEL SESSION 4B: Epigenomics and twin studies

Coordinators: Jeffrey Craig (Australia); Robert Lyle (Norway)

Methylome-wide association study of aggressive behavior in monozygotic twins
Jenny Van Dongen (Netherlands)

Hormone replacement therapy -related DNA methylation, gene expression and mir profiles associate with within-pair differences in clinical measures
Miina Ollikainen (Finland)

A genome-wide profiling of epigenetic fingerprint in adult twins of preterm birth.
Qihua Tan (Denmark)

The relevance of peripheral DNA methylation for human brain development and emotional functioning: studies in monozygotic twins
Linda Booij (Canada)

Circulating microRNA biomarkers and cognitive function in elderly Danish twins
Jonas Mengel-From (Denmark)

A twin model for making causal inference: applications to observational epigenetic associations
Shuai Li (Australia)

Cigarette smoking, circulating levels of immune and inflammatory markers and epigentics in monozygotic twins
Wendy Cozen (Unites States)

Epigenetic signatures of prenatal growth control
Marij Gielen (The Netherlands)

18.30 – 19.30

ISTS GENERAL MEETING

+ Sat 18th Nov

08.30 – 09.30

PARALLEL SESSION 5A: Care in pregnancy and labour

Course Coordinator: Eftichia Kontopoulos (USA); Gerard Visser (The Netherlands)

Fetal growth restriction in twin pregnancy
Mar Bennasar (Spain)

Intrapartum care in twins pregnancy
Efticha Kontopoulos (United States)

Can 3D printing help for the monitoring of twin pregnancy?
Irene Giardina (Italy); Graziano Clerici (Italy); Gian Carlo Di Renzo (Italy)

08.30 – 09.30

PARALLEL SESSION 5B: Polygenic Risk Scores and twin studies

Coordinator: Sarah Medland (Australia)

Construction and use of PRS
Sarah Medland (Australia)

PRS and the study of GxE interactions
Lucia Colodro Conde (Australia)

PRS in Mendelian Randomization
Baptiste Couvy-Duchesne (Australia)

09.30 – 10.00

KEYNOTE LECTURE 

Introduced by: Jennifer Harris (Norway)

Twin studies of obesity: an epigenetic and microbiome perspective
Jordanna Bell (United Kingdom)

10.00 – 10.30

COFFEE BREAK & POSTER WALK WITH FOCUS ON

– SPECIAL ISSUES: TTTS, TAPS, MCMA

10.30 – 12.30

PARALLEL SESSION 6A:  Special issues: TTTS, TAPS, MCMA

Coordinators: Ruben Quintero (USA); Mark Kilby (United Kingdom)

Management of MCMA twins
Kurt Hecher (Germany)

TTTS in triplets
Asma Khalil (United Kingdom)

Debate: traditional selective laser photocoagulation of communicating vessels (SLPCV) approach for managing TTTS
Ruben Quintero (USA) 

Brain abnormalities
Julien Stirnemann (France)

Long term neurodevelopmental outcome of MC twins
Jeanine van Klink (The Netherlands)

Fetoscopic laser photocoagulation in twin-to-twin transfusion syndrome
Kristina Gladkova (Russia)

10.30 – 12.30

PARALLEL SESSION 6B: Symposium in honor of Irv Gottesman 

Organizer: Nancy Segal (United States)
Discussant: Kaare Christensen (Denmark)

Dr. Irving I. Gottesman was a pioneer in the field of twin research, as well as a wonderful colleague, mentor and friend to the scores of individuals with whom he worked. This symposium honors his legacy and in doing so keeps it alive as an inspiration for future investigators. An overview of his professional contributions and papers from his former students and colleagues will be presented, followed by comments from the audience.

Introductory Remarks
Nancy Segal (United States)

Gene-Environment Correlations Affecting Children’s Early Delinquency and Aggressive Play Behaviors
Lisabeth Di Lalla and David Dilalla (United States)

From Genes to Behavior Through Sex Hormones and Socialization: The Example of Gender Development
Sheri Berenbaum, Adriene M. Beltz (United States)

Twins Reared Apart: The Findings Behind the Fascination
Nancy Segal (United States)

Irv Gottesman and the Possibilities for Theoretical Behavioral Genetics
Eric Turkheimer (United States)

Mapping Risk from Genes to Behavior
Danielle Dick (United States)

Comments and recollections from the audience

Closing Comments

12.30 – 13.30

LUNCH BREAK & POSTER WALK WITH FOCUS ON

– PERINATAL MORTALITY AND MORBIDITY IN MULTIPLE PREGNANCY

– PRENATAL SCREENING AND DIAGNOSIS IN TWINS PREGNANCY

13.30 – 15.30

PARALLEL SESSION 7A:  Delivery of twins: Cesarean delivery, PPH

Coordinators: Gerard H.A. Visser (The Netherlands); Jon F. Barrett (Canada)

When is the optimal timing to deliver uncomplicated twins?
Jon F. Barrett (Canada)

Mode of Delivery
Amala Nazareth (EAU)

Induction of labour in Twins
Maria De La Calle (Spain)

Prevention and management of PPH in multiple pregnancy
Anton Mikhailov (Russia)

Debate: all monochorionic twins should be delivered by CS
YES: Corinne Hubinont (Belgium)
NO: Jan G. Nijhuis (The Netherlands)

13.30 – 15.30

PARALLEL SESSION 7B: participant engagementand user involvement in twin research: let’s talk about lessons learned and ideas going forward

Coordinators: Jennifer Harris (Norway), Monica Rankin (Australia), Jeffrey Craig (Australia) 

Research funding agencies are increasingly focused on participant engagement and user involvement in the research process to help improve the quality and usefulness of the research.

What are the types of participant engagement and/or user involvement that twin studies have used and how have these helped in the research process? This session will include several short talks describing experiences and approaches with user involvement and engagement in twin studies. It is designed as an interactive session that will include a panel discussion.

User involvement and participant engagement
Jennifer Harris, Isabelle Budin-Ljøsne (Norway)

Strategies for participant engagement and lessons learned from ICOMBO
Monica Rankin (Australia)

Vietnam Era Registries: Engagement through focus groups
Nicolas Smith (USA)

Engaging with twins and their families – an Australian perspective
Jeff Craig (Australia)

Consent and feedback: Issues and Solutions
Gonneke Willemsen (The Netherlands)

 

 

Discussion Panel

Isabelle Budin-Ljøsne (Norway)

Thalia Eley (United Kingdom)

Jeff Craig (Australia)

Jack Goldberg (United States)

Monica Rankin (Australia)

Nancy Segal (United States)

Nicolas Smith (United States)

Gonneke Willemsen (The Netherlands)

15.30 – 16.30

COFFEE BREAK & POSTER WALK WITH FOCUS ON

– PRETERM BIRTH AND PREMATURITY

– TWIN-RELATED COMPLICATIONS

16.30 – 18.30

PARALLEL SESSION 8A:  Special issues: Infections, Maternal diseases

Coordinators: Liesbeth Lewi (Belgium); Jan G. Nijhuis (The Netherlands)

Insulin resistance and metabolic abnormalities in birthweight discordant twins

Iwona Szymusik, Miroslaw Wielgos (Poland)

Gestational diabetes and multiple pregnancy – A 10 year retrospective of obstetric complications and neonatal outcomes
Filipa Mendes Coutinho (Portugal)

Maternal morbidity according to chorionicity
Mark Kilby (United Kingdom)

The ELABELA-nergic Pathway as a Therapeutic Window for Pre-Eclampsia
Bruno Reversade (Singapore)

Thrombophilia and twin pregnancy
Liliana Voto (Argentina)

16.30 – 18.30

PARALLEL SESSION 8B: The use of twins in unravelling the Microbiome

Coordinators: Tim Spector (United Kingdom)

“Irritable Bowel Syndrome, Anxiety and Gut Microbiome – the Korean Healthy Twin Study”
Joohon Sung (South Korea)

Novel Twin Microbiome studies in Twins UK
Claire Steves (United Kingdom)

Differences in fecal microbiota in long-term hodgkin lymphoma survivors and their unaffected twins
Wendy Cozen (United States)

Cognitive performance is associated with the gut microbiota of community dwelling ageing adults
Serena Verdi (United Kingdom)

16.30 – 18.30

ICOMBO Business Meeting

18.30

CLOSING REMARKS